Endocrine Abstracts

Introduction: Non-classical congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency is one of the most frequent autosomal recessive diseases. Genetic analysis performed for genetic counselling revealed a miscorrelation with the clinical diagnosis in several patients at our centre.Aim: Confirm the genetic diagnosis of NCCAH in women attended for this condition.Materials and methods: Consecutive patients attended at o...

Introduction: Pituitary tumors can be classified according to their endocrine function, starting from the clinical phenotype to establish a diagnosis. The histological analysis can confirm the clinical suspicion. A thorough classification is essential in the therapeutic approach with an important influence in the disease-free survival.Case report: We report a case of a 16-year-old male, with loss of visual acuity and headache, attended by an Ophthalmolog...

Introduction: Cushing’s disease (CD) is a Grave disease that requires a multidisciplinary and individualized treatment approach.Case report: We describe the case of a 31-years old female patient with Cushing disease diagnosed in 2007. She initially complained of weight fluctuations, amenorrheia, rounded face with plethora and acne, for 1 year duration. Analytically: 0800 h plasma cortisol of 14 μg/dl (5–25) and 2300 h 15 μg/dl, ACTH 1...

Objective: Relationship between pre-pregnancy BMI (PPBMI) in gestational diabetic (GD) patients, and age, country of origin, family history of type 2 diabetes mellitus (T2DM), GD history, and BMI after pregnancy.Methods: Transversal, descriptive study of 259 consecutive pregnant with confirmed DG. Analysis were based on Fisher’s exact test and Student’s t-test. A P<0.05 was significant (SPSS 19.0).Re...

Introduction: Type one diabetes is estimated to account for 1% of the pregnancies complicated by diabetes, associated with an increased risk of maternal and perinatal morbidity. The multidisciplinary follow up of the diabetic women can contribute to an improvement of the glycemic control, minimizing the obstetric and perinatal complications.Aims: To characterize pregnant women with type one diabetes followed in our Department’s Endocrinology/Obstetr...

Objective: To evaluate the characteristics and glycemic control in admitted patients with type 2 diabetes and high vascular risk. To analyze therapeutic switch effect at hospital discharge on medium term metabolic control.Methods: Cross-sectional study including patients with type 2 diabetes and high vascular risk. Demographic and clinical characteristics, laboratory parameters, and diabetes treatment at baseline and discharge were analized. We used a sp...

The parallel increase in the amount of environmental contaminants and in the prevalence of some human diseases has led to a growing interest in understanding how these compounds, so-called endocrine disruptors, may affect human health. In this scenario, the concept that obesity is the result of the interplay of genetic and lifestyle factors has been changing due to the growing evidence that environmental contaminants might alter endocrine function.Organo...

Polycystic ovary syndrome (PCOS) is an important metabolic and reproductive disorder which confers substantially increased risk for type two diabetes and metabolic syndrome (MS). Our aim is to characterize the metabolic profile, insulin sensitivity (IS) and insulin secretion in control (Cw) and PCOS women (PCOSw) during different stages of reproductive life (S1: 18–35 years old, S2: 36–44 years old, S3: 45–55 years old). A total of 131 Cw and 129 PCOSw were incl...

Introduction: Radiation therapy is an effective treatment for relapsing or recurrent pituitary functioning adenomas, providing tumor volume control and hormone secretion normalization. However, there are several secondary effects to consider.Aims: To assess the efficacy of radiotherapy in the management of patients with acromegaly and Cushing’s disease (CD) treated in our Department, and the prevalence of radiation secondary effects.<p class="ab...

Introduction: Our group has a bank of human primary thyroid cultures (BANTTIC) obtained from patients. All are individual cultures specifically genotyped and phenotyped. We believe of great interest the search for biomarkers in these cultures using differential proteomic analysis.We have applied differential proteomics using 2D-PAGE coupled to MALDI-TOF-TOF-MS. We have compared benign pathologies (normal thyroid and Pendred’s syndrome) and different...